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Fig. 1. Exosome biogenesis: The early endosomes mature into late endosomes or MVBs in an ESCRT-dependent pathway, including ESCRT-0, I, II, and III proteins, followed by inward budding to generate intraluminal vesicles (ILVs). MVBs then combine with the plasma membrane or lysosome to secrete ILVs to release them as exosomes by exocytosis. However, the ESCRT-independent pathway may generate exosomes involving lipids (such as sphingomyelin and ceramide) and <t>tetraspanins</t> for exosome production. ESCRT- Endosomal Sorting Complex Required for Transport, MVB- multivesicular bodies, ILVs: Intraluminal vesicles).
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Fig. 1. Exosome biogenesis: The early endosomes mature into late endosomes or MVBs in an ESCRT-dependent pathway, including ESCRT-0, I, II, and III proteins, followed by inward budding to generate intraluminal vesicles (ILVs). MVBs then combine with the plasma membrane or lysosome to secrete ILVs to release them as exosomes by exocytosis. However, the ESCRT-independent pathway may generate exosomes involving lipids (such as sphingomyelin and ceramide) and tetraspanins for exosome production. ESCRT- Endosomal Sorting Complex Required for Transport, MVB- multivesicular bodies, ILVs: Intraluminal vesicles).

Journal: Biochemical and biophysical research communications

Article Title: The role of exosomes in diagnosis, pathophysiology, and management of Alzheimer's Disease.

doi: 10.1016/j.bbrc.2025.151526

Figure Lengend Snippet: Fig. 1. Exosome biogenesis: The early endosomes mature into late endosomes or MVBs in an ESCRT-dependent pathway, including ESCRT-0, I, II, and III proteins, followed by inward budding to generate intraluminal vesicles (ILVs). MVBs then combine with the plasma membrane or lysosome to secrete ILVs to release them as exosomes by exocytosis. However, the ESCRT-independent pathway may generate exosomes involving lipids (such as sphingomyelin and ceramide) and tetraspanins for exosome production. ESCRT- Endosomal Sorting Complex Required for Transport, MVB- multivesicular bodies, ILVs: Intraluminal vesicles).

Article Snippet: Exosome-enriched transmembrane proteins named tetraspanins also trigger exosome release in an ESCRT-independent manner.

Techniques: Clinical Proteomics, Membrane